"Local" wineries outside the major production areas can be interesting, fun, surprising and rewarding. As to being your "best bet" for "good," no. Unless it's a very special winery indeed (and heaven knows, I'm certainly not familiar with anywhere near most of them), the mind boggles. There are sound climate and soil reasons the big areas are the big areas. With respect and affection for Indiana, it isn't Napa or the Loire.