Hi Randy. I use pressure cookers on a regular basis. Cooking with wine or beer is perfectly fine, since aside from being alcoholic, they also produce the steam required to bring the appliance up to pressure. Be sure to follow manufacturer's instructions regarding the minimum amount of liquid needed for pressure. For instance, if the manual says 1/2 cup liquid per each 15 minutes cooking time, and you are making a roast that calls for 45 min under pressure, you will need to use no less than 1 1/2 cups liquid. The liquid may be all wine, all beer, or any combination of alcohol and other steam-producing liquid, such as water, juice, cidar, vinegar, etc, or any combination. Avoid milk. Milk froths, and also scorches...so even though it produces steam, it also makes for big problems.