I think that I would have to choose the Alsace region of France. Sure there are better areas of France for wines, food, or culture. I can't think of a better place where all three of these combine along with the mixing of French and German cultures (two of my favorite cuisines and cultures). Sure, this may not be as exotic as some places (you can go anywhere), but this is the cuisine and culture that I truly love. Add to that, the rich history of the place and I would be in heaven.
How about you?